Progress on the role of mitophagy in myocardial ischemia-reperfusion injury

oleh: MA Congcong, LIU Yang, LYU Yang, WANG Haiping

Format: Article
Diterbitkan: Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. 2023-11-01

Deskripsi

Myocardial ischemia-reperfusion injury (MI/RI) is potentially associated with activation of mitophagy through a variety of molecular mechanisms. Moderate mitophagy is effective in maintaining mitochondrial membrane potential and cell membrane structure and function, thereby reducing MI/RI, whereas mitochondrial dysfunction, inadequate clearance or over-activated mitophagy can make MI/RI more severe.