Clinical and Molecular Epidemiology of Invasive Group B Streptococcus Disease among Infants, China
oleh: Wenjing Ji, Haiying Liu, Shabir A. Madhi, Marianne Cunnington, Zilu Zhang, Ziyaad Dangor, Haijian Zhou, Xiaoping Mu, Zhengjiang Jin, Aimin Wang, Xiaosong Qin, Chunyan Gao, Yuning Zhu, Xiaodan Feng, Shangyang She, Shuhua Yang, Jing Liu, Jine Lei, Lan Jiang, Zeshi Liu, Gang Li, Qiuhong Li, Qiulian Deng, Kankan Gao, Yu Fang
| Format: | Article |
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| Diterbitkan: | Centers for Disease Control and Prevention 2019-11-01 |
Deskripsi
Invasive group B Streptococcus (GBS) remains a leading cause of illness and death among infants globally. We conducted prospective and retrospective laboratory-based surveillance of GBS-positive cultures from infants <3 months of age in 18 hospitals across China during January 1, 2015–December 31, 2017. The overall incidence of GBS was 0.31 (95% CI 0.27–0.36) cases/1,000 live births; incidence was 0–0.76 cases/1,000 live births across participating hospitals. The case-fatality rate was 2.3%. We estimated 13,604 cases of GBS and 1,142 GBS–associated deaths in infants <90 days of age annually in China. GBS isolates were most commonly serotype III (61.5%) and clonal complex 17 (40.6%). Enhanced active surveillance and implementation of preventive strategies, such as maternal GBS vaccination, warrants further investigation in China to help prevent these infections.