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Abstract Over the last few years, significant attention has been devoted to studying the kagome materials A V3Sb5 (A = K, Rb, Cs) due to their unconventional superconductivity and charge density wave (CDW) ordering. Recently $${{{{\rm{ScV}}}}}_{6}{{{{\rm{Sn}}}}}_{6}$$ ScV 6 Sn 6 was found to host a CDW below ≈ 90 K, and, like A V3Sb5, it contains a kagome lattice comprised only of V ions. Here we present a comprehensive magnetotransport study on $${{{{\rm{ScV}}}}}_{6}{{{{\rm{Sn}}}}}_{6}$$ ScV 6 Sn 6 . We discovered several anomalous transport phenomena above the CDW ordering temperature, including insulating behavior in interlayer resistivity, a strongly temperature-dependent Hall coefficient, and a violation of Kohler’s rule. All these anomalies can be consistently explained by a progressive decrease in carrier densities with decreasing temperature, suggesting the formation of a pseudogap. Our findings suggest that high-temperature CDW fluctuations play a significant role in determining the normal state electronic properties of $${{{{\rm{ScV}}}}}_{6}{{{{\rm{Sn}}}}}_{6}$$ ScV 6 Sn 6 .