Hecw controls oogenesis and neuronal homeostasis by promoting the liquid state of ribonucleoprotein particles
oleh: Valentina Fajner, Fabio Giavazzi, Simona Sala, Amanda Oldani, Emanuele Martini, Francesco Napoletano, Dario Parazzoli, Giuliana Cesare, Roberto Cerbino, Elena Maspero, Thomas Vaccari, Simona Polo
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-09-01 |
Deskripsi
Ribonucleoprotein (RNP) granules are responsible for mRNA transport and local translation required for neuronal and oocyte maturation. Here the authors show that loss of the Drosophila Ub ligase Hecw enlarges RNP granules, leads to a liquid to gel-like transition, and results in defective oogenesis and neuronal loss.