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A 31-year-old woman with cystic fibrosis (CF) presents with a rightsided obstructive pyeloureteral junction stone complicated by urosepsis. Following an emergency treatment with ureteral stent placement, she is transferred to the intensive care unit for symptoms of septic shock and hemodynamic instability. Her clinical history reveals an exocrine pancreatic insufficiency and bilateral lung transplantation, both related to CF.