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Background: The switch to the hospital-based course represents a significant stressful change in medical students’ experience. Objective: To investigate the anxiety levels in students in various clinical situations. Method: A 40-item questionnaire based study was conducted to assess students’ anxieties about potential anxiety provoking clinical situations and respondent ratings were requested for each of the 40 items on the list. Results: ‘Getting diagnoses wrong’ was the biggest worry overall and of male students whereas female students were most anxious about ‘talking with dying patients’. The overall mean anxiety scores for males and females were not different. Females compared to males had statistically higher anxiety scores in only 2/40 situations. Conclusions: Pre-clinical students should have early introduction to clinical and community settings.