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<p class="abstract"><strong>Abstract</strong></p> <p class="abstract"><strong>&nbsp;&nbsp; BACKGROUND:</strong> Leptin, the product of the ob gene, could have a role in the pathogenesis of obesity and non-insulin dependent diabetes mellitus (NIDDM). The aim of this study was to investigate relationships between serum leptin concentration and insulin, glucose, HbA1c levels and insulin resistance in diabetic women.</p> <p class="abstract"><strong>&nbsp;&nbsp; METHODS:</strong> We studied 45 diabetic women and 45 healthy women (controls) who aged 45-60 years and had BMI of 25-30 kg/m². Serum leptin, insulin, HbA1c, fasting blood sugar and insulin resistance were determined in the two groups.</p> <p class="abstract"><strong>&nbsp;&nbsp; RESULTS:</strong><strong> </strong>There was a significant positive correlation between leptin and insulin (r = 0.295, P = 0.049) and insulin resistance (r = 0.329, P = 0.027) in controls but non-significant correlation between leptin and HbA1c and fasting blood sugar were observed in the two groups.</p> <p class="abstract"><strong>&nbsp;&nbsp; </strong><strong>CONCLUSION:</strong> This study did not document any significant relationship between serum leptin and insulin, glucose, HbA1c and insulin resistance in diabetic women.</p> <p class="abstract">&nbsp;</p><table cellspacing="0" cellpadding="0" align="left"><tbody><tr><td width="35" height="12"><br /></td></tr> <tr><td><br /></td> <td>&nbsp;</td></tr></tbody></table><p class="abstract">&nbsp;</p> <br /> <p class="abstract"><strong>Keywords:</strong> Type 2 Diabetes Mellitus, Leptin, Insulin.</p>