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Progesterone hypersensitivity (PH) is a rare clinical condition that  displays hypersensitivity to  endogenous  or  exogenous progesterone.  It  is characterized by cyclic dermatologic manifestations at the end of the luteal phase that disappear some days after menses. We present  a  case of  24-year-old woman  showing severe angioedema attacks occurring from the first day of her menstruation and continuing for 4-5 days and having positive progesterone intradermal test (IDT). To our knowledge, there is no case in the literature which is coupled with PH isolated angioedema attacks. In this case report we will discuss diagnostic value of progesterone IDT.