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This paper is based on the Takagi-Sugeno (T-S) fuzzy models to construct a coronary artery system (CAS) T-S fuzzy controller and considers the uncertainties of system state parameters in CAS. We propose the fuzzy model of CAS with uncertainties. By using T-S fuzzy model of CAS and the use of parallel distributed compensation (PDC) concept, the same fuzzy set is assigned to T-S fuzzy controller. Based on this, a PDC controller whose fuzzy rules correspond to the fuzzy model is designed. By constructing a suitable Lyapunov-Krasovskii function (LKF), the stability conditions of the linear matrix inequality (LMI) are exported. Simulation results show that the method proposed in this paper is correct and effective and has certain practical significance.