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Bifidobacteria are known to inhibit, compete with and displace the adhesion of pathogens to human intestinal cells. Previously, we demonstrated that goat milk oligosaccharides (GMO) increased the attachment of <i>Bifidobacterium longum</i> subsp. <i>infantis</i> ATCC 15697 to intestinal cells in vitro. In this study, we aimed to exploit this effect as a mechanism for inhibiting pathogen association with intestinal cells. We examined the synergistic effect of GMO-treated <i>B. infantis</i> on preventing the attachment of a highly invasive strain of <i>Campylobacter jejuni</i> to intestinal HT-29 cells. The combination decreased the adherence of <i>C. jejuni</i> to the HT-29 cells by an average of 42% compared to the control (non-GMO treated <i>B. infantis</i>). Increasing the incubation time of the GMO with the <i>Bifidobacterium</i> strain resulted in the strain metabolizing the GMO, correlating with a subsequent 104% increase in growth over a 24 h period when compared to the control. Metabolite analysis in the 24 h period also revealed increased production of acetate, lactate, formate and ethanol by GMO-treated <i>B. infantis</i>. Statistically significant changes in the GMO profile were also demonstrated over the 24 h period, indicating that the strain was digesting certain structures within the pool such as lactose, lacto-<i>N</i>-neotetraose, lacto-<i>N</i>-neohexaose 3&#8242;-sialyllactose, 6&#8242;-sialyllactose, sialyllacto-<i>N</i>-neotetraose c and disialyllactose. It may be that early exposure to GMO modulates the adhesion of <i>B. infantis</i> while carbohydrate utilisation becomes more important after the bacteria have transiently colonised the host cells in adequate numbers. This study builds a strong case for the use of synbiotics that incorporate oligosaccharides sourced from goat&#8242;s milk and probiotic bifidobacteria in functional foods, particularly considering the growing popularity of formulas based on goat milk.