First Female Patient with a Rare CIC-FOXO4-Translocated Sarcoma: A Case Report

oleh: Aryeh Babkoff, Yael Berner-Wygoda, Judith Diment, Anatoli Kustanovich, Aviad Zick, Daniela Katz, Albert Grinshpun

Format: Article
Diterbitkan: Karger Publishers 2023-09-01

Deskripsi

Small round cell sarcoma is a group of undifferentiated malignancies arising in the bone and soft tissue, notable for Ewing sarcoma. Recently, a new World Health Organization classification has been introduced, including an additional subset of these sarcomas, named CIC-rearranged sarcoma. Within this group, CIC-FOXO4 translocation is an exceedingly rare fusion that has been reported only 4 times in the literature. Herein, we report in-depth the pathological, clinical, and molecular features of a CIC-FOXO4 translocation-driven tumor in a 46-year-old woman.