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Aims: Microleakage under brackets and bands are considered one of the common problems that occur during orthodontic treatments. The main objective of this paper was to review the available information regarding the factors contributing to microleakage in Orthodontics. Materials and Methods: Microleakage was defined, and reviewed and explained the factors contributing to microleakage in orthodontics. Conclusion: A considerable amount of research has been published concerning factors contributing to microleakage in orthodontics. this paper hopes to provide some information regarding this topic for both researchers and people working in clinical fields.