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Regional development in the Czech Republic contributed to the fact that at present none of the regions is significant backward compared to other. Individual regions have shown among themselves certain differences. This applies in particular to the economic performance of regions. This paper introduce results of our research. Main aim of the work was to indentify economic performace affecting factors of regions NUTS 3 in Czech Republic. It was necessary to define quantity of economic performance to meet this goal. We used them to create method of valuating economic performance of regions. We weighed quantities (e.g. GDP, unemployment rate, net disposable income) according to their importance. This procedure was applied to individual regions. We determined the level of economic performance of Czech regions. We present overview of factors and using statistical methods we test their importance to the economic performance of Czech regions.