Differential nuclear import sets the timing of protein access to the embryonic genome
oleh: Thao Nguyen, Eli J. Costa, Tim Deibert, Jose Reyes, Felix C. Keber, Miroslav Tomschik, Michael Stadlmeier, Meera Gupta, Chirag K. Kumar, Edward R. Cruz, Amanda Amodeo, Jesse C. Gatlin, Martin Wühr
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-10-01 |
Deskripsi
Here the authors address how embryos control the timing of specific gene activation in early frog development. They find transcription factors for early gene activation are maternally loaded and remain at constant levels, and rather that order of activation is based on their sequential entry into the nucleus based largely on their respective affinity to importins.