Iodobenzene-Promoted Pd-Catalysed ortho-Directed C–H Activation: The Synthesis of Benzothiazoles via Intramolecular Coupling
oleh: Meng-Tian Zeng, Wan Xu, Min Liu, Xing Liu, Cai-Zhu Chang, Hui Zhu, Zhi-Bing Dong
| Format: | Article |
|---|---|
| Diterbitkan: | Georg Thieme Verlag KG 2017-03-01 |
Deskripsi
Abstract A series of 2-aminobenzothiazoles were synthesized by a palladium-catalysed oxidative coupling with good yields (62–89%). Iodobenzene was found to be effective as an additive in this intramolecular C–S bond-formation reaction. The directing thiourea group attached to the aryl ring is essential for the activation of the ortho C–H bond.