Palladium-NHC Catalyzed Enantioselective Synthesis of Fused Indolines via Inert C(sp3)-H Activation
oleh: Masafumi Nakanishi, Dmitry Katayev, Céline Besnard, E. Peter Kündig
| Format: | Article |
|---|---|
| Diterbitkan: | Swiss Chemical Society 2012-04-01 |
Deskripsi
New sterically hindered chiral N-heterocyclic carbene (NHC) ligands were used in palladium catalysis to bring about a highly enantioselective C(sp3)-H activation on the methylene site of a cycloalkane moiety. The intramolecular coupling reaction of a prochiral N-aryl-N-cycloalkyl methyl carbamate required high temperatures (140–160 °C) and afforded highly enantioenriched trans-2,3-fused indolines.