The Nitrofuran-Warhead-Equipped Spirocyclic Azetidines Show Excellent Activity against <i>Mycobacterium tuberculosis</i>
oleh: Kristina Komarova, Lyubov Vinogradova, Alexey Lukin, Maxim Zhuravlev, Dmitry Deniskin, Mikhail Chudinov, Maxim Gureev, Marine Dogonadze, Natalia Zabolotnykh, Tatiana Vinogradova, Anastasia Lavrova, Petr Yablonskiy
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2024-06-01 |
Deskripsi
A series of 21 new 7′H-spiro[azetidine-3,5′-furo [3,4-d]pyrimidine]s substituted at the pyrimidine ring second position were synthesized. The compounds showed high antibacterial in vitro activity against <i>M. tuberculosis</i>. Two compounds had lower minimum inhibitory concentrations against <i>Mtb</i> (H37Rv strain) compared with isoniazid. The novel spirocyclic scaffold shows excellent properties for anti-tuberculosis drug development.