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Association of acute myeloid leukaemia with bone marrow plasmacytosis is a rare phenomenon with diverse underlying pathogenetic mechanisms. We report a case of a 75 years old diabetic male diagnosed as suffering with plasmacytosis. There were no lytic bone lesions or Bence‐Jones proteinuria. Serum protein electrophoresis did not show a monoclonal band. A presumptive diagnosis of AML with reactive plasmacytosis was made. Possible conditions which can be considered in differential diagnosis are discussed.