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Using a science mapping approach, we analyzed the exponential increase in the number of scientific documents about the negative environmental impacts produced by waste from personal protective equipment (PPE), especially face masks, used to reduce SARS-CoV-2 transmission worldwide. Our results revealed that India, China, and Canada are leaders in this research field, which is clearly related to environmental issues, but also the solutions developed from an engineering point of view. Our analysis of the most-relevant documents in the field uncovered the considerable negative effects of PPE waste in aquatic media, its contribution to greenhouse gas emissions, effects on wildlife, etc. To reduce the negative environmental impacts of PPE waste, we need to implement innovative ecodesign strategies for their green production, including their re-use as and the use of recycling materials, but also a collaboration with the population to reduce PPE waste at its source. Both action lines could be materialized by establishing a collective, extended producer responsibility system for PPE to ensure their sustainable production and consumption. These well-implemented strategies will contribute to maintaining progress towards achieving sustainable development goals.