Single-cell multiomics sequencing reveals the functional regulatory landscape of early embryos
oleh: Yang Wang, Peng Yuan, Zhiqiang Yan, Ming Yang, Ying Huo, Yanli Nie, Xiaohui Zhu, Jie Qiao, Liying Yan
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-02-01 |
Deskripsi
Extensive epigenetic reprogramming occurs during preimplantation embryo development. Here the authors develop a single cell multiomics sequencing technology that enables profiling of genome-wide chromatin accessibility, DNA methylation and RNA expression in the same individual cell and apply this method to study mouse preimplantation embryos.