Caveolin-1-mediated sphingolipid oncometabolism underlies a metabolic vulnerability of prostate cancer
oleh: Jody Vykoukal, Johannes F. Fahrmann, Justin R. Gregg, Zhe Tang, Spyridon Basourakos, Ehsan Irajizad, Sanghee Park, Guang Yang, Chad J. Creighton, Alia Fleury, Jeffrey Mayo, Adriana Paulucci-Holthauzen, Jennifer B. Dennison, Eunice Murage, Christine B. Peterson, John W. Davis, Jeri Kim, Samir Hanash, Timothy C. Thompson
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2020-08-01 |
Deskripsi
The mechanisms associated with Caveolin-1 (Cav-1) mediated metabolic changes in prostate cancer are unclear. Here, the authors show that Cav-1 promotes rewiring of cancer cell lipid metabolism towards a program of exogenous lipid scavenging and vesicle biogenesis that intersects with mitochondrial dynamics in prostate tumors.