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A promising alternative to methods for the conventional medical diagnosis of many disorders is respiratory monitoring. Unfortunately, current respiratory monitoring methods can be expensive and require inconvenient equipment, significantly limiting their medical applicability. In this study, we fabricated a respiration sensor that uses MoS₂-based resistance measurements and analyzed the cause of the slow response time previously reported for MoS₂-based sensors. Our results confirm that the crystal phase change of MoS₂ affects the absorption and desorption of H₂O and the use of the 2H structure results in high sensitivity, a fast response time, and a linear response to water vapor absorption during breathing. This study demonstrates the potential of two-dimensional nanomaterials for humidity and respiration sensors that can be applied in various fields.