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Total synthesis of atropurpuran
oleh: Jing Gong, Huan Chen, Xiao-Yu Liu, Zhi-Xiu Wang, Wei Nie, Yong Qin
Format: | Article |
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Diterbitkan: | Nature Portfolio 2016-07-01 |
Deskripsi
Polycyclic and caged molecules are common in nature but present challenging targets for synthesis. Here, the authors report a route to caged diterpene cores and apply to the total synthesis of atropurpuran, with oxidative dearomatization/intramolecular Diels-Alder cascade, aldol and ketyl-olefin cyclizations as key steps.