Total synthesis of atropurpuran

oleh: Jing Gong, Huan Chen, Xiao-Yu Liu, Zhi-Xiu Wang, Wei Nie, Yong Qin

Format: Article
Diterbitkan: Nature Portfolio 2016-07-01

Deskripsi

Polycyclic and caged molecules are common in nature but present challenging targets for synthesis. Here, the authors report a route to caged diterpene cores and apply to the total synthesis of atropurpuran, with oxidative dearomatization/intramolecular Diels-Alder cascade, aldol and ketyl-olefin cyclizations as key steps.