Síntese, avaliação biológica e modelagem molecular de arilfuranos como inibidores da enzima tripanotiona redutase Synthesis, biological evaluation and molecular modeling of arylfurans as potential trypanothione reductase inhibitors
oleh: Renata B. de Oliveira, Carlos L. Zani, Rafaela S. Ferreira, Rodrigo S. Leite, Tânia M. A. Alves, Thaís H. A. da Silva, Alvaro J. Romanha
| Format: | Article |
|---|---|
| Diterbitkan: | Sociedade Brasileira de Química 2008-01-01 |
Deskripsi
<abstract language="eng">Trypanosoma cruzi is a protozoan parasite that causes a severe disease (Chagas'disease) in Central and South America. The currently available chemotherapeutic agents against this disease are still inadequate. The enzyme trypanothione reductase (TR) is considered a validated molecular target for the development of new drugs against this parasite. In this regard, a series of arylfurans based on 2,5-bis-(4-acetamidophenyl)furan was synthesized and tested for their in vitro inhibitory activity against TR. Molecular modeling studies of putative enzyme-inhibitor complexes revealed a possible mechanism of interaction. From synthesized compounds, a benzylaminofuran derivative was found to be more active than the lead compound.