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In the aquatic environment, substances of pharmacological origin are common contaminants. The difficulty of removing them from water is a problem for the implementation of a circular economy policy. When recycling water, an effort should be made to remove, or at least, minimize the presence of these substances in the water. Porous membranes with a new functionality consisting in their adsorption capacity towards pharmaceutical substances have been developed. A Polyvinylidene Fluoride (PVDF) membrane with Calcium Carbonate (CaCO₃) nanoparticles as an adsorbent was prepared. By implementing an integrated filtration-adsorption process using sulphadiazine, as a representative of pharmacological substances, 57 mg/m² of adsorption capacity has been obtained, which is an improvement in adsorption properties of more than 50 times that of a commercial membrane. At the same time the membrane permeability is 0.29 m³/(h·m²·bar), which means that the membrane’s permeability was improved by 75%.