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The present study analyses the chemical reaction effect on a boundary layer flow of an electrically conducting micropolar fluid subject to transverse magnetic field along a vertical plate with variable wall temperature and concentration. The governing nonlinear partial differential equations are transformed into a system of coupled nonlinear ordinary differential equations by applying similarity transformations and then solved using Runge–Kutta fourth order scheme followed by shooting technique. The striking features of the analysis are (i) the destructive chemical reaction parameter overrides the effect of resistive magnetic force on velocity field, (ii) the coupling parameter decreases the velocity and (iii) the higher solutal stratification is desirable in controlling the growth of solutal boundary layer.