Polyoxygenated Terpenoids and Polyketides from the Roots of <i>Flueggea virosa</i> and Their Inhibitory Effect against SARS-CoV-2-Induced Inflammation
oleh: Ju-Chien Cheng, Yi-Ju Chen, Chi-Wen Chuang, Ya-Hsuan Chao, Hui-Chi Huang, Chia-Chi Lin, Chih-Hua Chao
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2022-12-01 |
Deskripsi
Six new polyoxygenated terpenoids, podovirosanes A–F (<b>1</b>–<b>6</b>), and two known polyketides (<b>7</b> and <b>8</b>) were isolated from the roots of <i>F. virosa</i>. Their structures, along with absolute configurations, were deduced using spectroscopic analysis as well as computational calculations, including TDDFT calculation of ECD spectra and GIAO NMR calculations combined with DP4+ probability analysis. Compounds <b>2</b>, <b>3</b>, <b>5</b>, and <b>8</b> were found to reduce the phosphorylation levels of NF-<i>κ</i>B p65 in SARS-CoV-2 pseudovirus-stimulated PMA-differentiated THP-1 cells.