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Heracleum moellendorffii Hance is a traditional widely used medicinal plant in China, also known for an edible wild herb. The complete chloroplast genome of H. moellendorffii was 149,349 bp in length, composed of a large single-copy (LSC) and a small single-copy (SSC) region joined by two identical inverted repeat regions (IRA and IRB). The cp genome contained 130 genes, including 85 protein-coding genes, eight rRNA genes, and 37 tRNA genes. The GC content was 37.5%. Phylogenetic tree indicated that H. moellendorffii was close to Pastinaca pimpinellifolia.