Triton X-100 catalyzed synthesis of α-aminophosphonates
oleh: Nemallapudi Bakthavatchala Reddy, Chereddy Syama Sundar, Chinthaparthi Radha Rani, Kunda Uma Maheswara Rao, Sandip Kumar Nayak, Cirandur Suresh Reddy
| Format: | Article |
|---|---|
| Diterbitkan: | Elsevier 2016-09-01 |
Deskripsi
Synthesis of α-aminophosphonates by a three-component condensation of an aldehyde, amines and dialkyl phosphites in the presence of a non-ionic surfactant Triton X-100 catalyst at 70 °C in aqueous medium is accomplished. The advantages are high yield, mild reaction conditions, simple work-up and eco-friendliness. All the newly-synthesized compounds (4a–j) exhibited moderate in vitro antibacterial and antifungal activities.