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Abstract Background Alendronate is used to treat Paget's bone disease, glucocorticoid‐induced osteoporosis, and postmenopausal osteoporosis because it suppresses osteoclast activity to stop bone resorption. Case report We present an exceptional case of esophagitis caused by alendronate. Blood tests and other data were normal when the patient was taken to the hospital, but an endoscopic examination revealed significant esophageal redness, erosion, and ulceration, along with pseudomembrane. The patient was given medicine after receiving a diagnosis of alendronate pill‐induced esophagitis based on the pathological findings. Conclusion This case report is a timely reminder of the importance of thorough pharmacovigilance, patient education, and smart therapeutic decision‐making in the context of alendronate use. To properly treat and prevent problems with the esophagus caused by alendronate, additional research is required.