SARS-CoV-2 Antibodies Are Persisting in Saliva for More Than 15 Months After Infection and Become Strongly Boosted After Vaccination
oleh: Yudi T. Pinilla, Yudi T. Pinilla, Constanze Heinzel, Constanze Heinzel, Lena-Fabienne Caminada, Douglas Consolaro, Douglas Consolaro, Meral Esen, Meral Esen, Meral Esen, Meral Esen, Peter G. Kremsner, Peter G. Kremsner, Peter G. Kremsner, Jana Held, Jana Held, Jana Held, Andrea Kreidenweiss, Andrea Kreidenweiss, Andrea Kreidenweiss, Rolf Fendel, Rolf Fendel, Rolf Fendel
| Format: | Article |
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| Diterbitkan: | Frontiers Media S.A. 2021-12-01 |
Deskripsi
SARS-CoV-2 antibodies in saliva serve as first line of defense against the virus. They are present in the mucosa, more precisely in saliva, after a recovered infection and also following vaccination. We report here the antibody persistence in plasma and in saliva up to 15 months after mild COVID-19. The IgG antibody response was measured every two months in 72 participants using an established and validated in-house ELISA assay. In addition, the virus inhibitory activity of plasma antibodies was assessed in a surrogate virus neutralization test before and after vaccination. SARS-CoV-2-specific antibody concentrations remained stable in plasma and saliva and the response was strongly boosted after one dose COVID-19 vaccination.