Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance
oleh: Valerie Barbier, Johanna Erbani, Corrine Fiveash, Julie M. Davies, Joshua Tay, Michael R. Tallack, Jessica Lowe, John L. Magnani, Diwakar R. Pattabiraman, Andrew C. Perkins, Jessica Lisle, John E. J. Rasko, Jean-Pierre Levesque, Ingrid G. Winkler
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-04-01 |
Deskripsi
The cell adhesion molecule E-selectin regulates haematopoietic stem cell self-renewal in the bone marrow vascular niche. Here, the authors show E-selectin adhesion directly induces survival signaling in acute myeloid leukaemia and therapeutic inhibition improves chemotherapy outcomes in mice.