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Anticholinergics are substances that antagonize the activity of the neurotransmitter acetylcholine. Anticholinergic syndrome (AS) occurs following a suicidal overdose, accidental drug intake, drug incompatibilities, and intake of multiple drugs simultaneously. Herein, we present two patients who were brought to the emergency room in a delirium state and were diagnosed with AS, presented other symptoms of anticholinergic toxidrome, and were treated with physostigmine.