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The pandemic caused by severe acute respiratory syndrome coronavirus 2 has had health implications of unprecedented magnitude. The second wave of the pandemic hit India with a tremendous rise in the number of patients requiring care not only for the viral inflammatory disease but also for secondary infections. Nearly 6–7 new patients of rhino-orbito-cerebral mucormycosis with active or resolved COVID-19 infection are reporting daily at a tertiary institute in Northern India. This another battle against an epidemic of mucormycosis, within an already established ongoing war of COVID-19 pandemic has aroused a need to understand the causal factors and implement effective prevention and control programs. The authors performed a thorough literature review in PubMed to understand the correlation between the two diseases. This review summarizes the plausible risk factors, and environmental determinants of mucormycosis in COVID-19, that are of particular importance to public health professionals.