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Soluble amyloid-β oligomers (oAβ₄₂)-induced neuronal death and inflammation response has been recognized as one of the major causes of Alzheimer’s disease (AD). In this work, a novel strategy adopting silica-coated iron oxide stir bar (MSB)-based AD therapy system via magnetic stirring-induced capture of oAβ₄₂ into magnetic plaques (mpAβ₄₂) and activation of microglia on cellular plaque clearance was developed. With oAβ₄₂ being effectively converted into mpAβ₄₂, the neurotoxicity toward neuronal cells was thus greatly reduced. In addition to the good preservation of neurite outgrowth through the diminished uptake of oAβ₄₂, neurons treated with oAβ₄₂ under magnetic stirring also exhibited comparable neuron-specific protein expression to those in the absence of oAβ₄₂. The phagocytic uptake of mpAβ₄₂ by microglia was enhanced significantly as compared to the counterpart of oAβ₄₂, and the M1 polarization of microglia often occurring after the uptake of oAβ₄₂ restricted to an appreciable extent. As a result, the inflammation induced by pro-inflammatory cytokines was greatly alleviated.