Type III ATP synthase is a symmetry-deviated dimer that induces membrane curvature through tetramerization
oleh: Rasmus Kock Flygaard, Alexander Mühleip, Victor Tobiasson, Alexey Amunts
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-10-01 |
Deskripsi
Mitochondrial ATP synthases are involved in shaping the mitochondrial cristae. The cryo-EM structure of type III ATP synthase reveals the architecture of the unusual, asymmetrical, U-shaped dimer and offers insights into the interaction with the natural inhibitor IF1 and membrane lipids. The structure of the enzyme tetramer suggests the mechanism of membrane curvature generation.