Mediator complex interaction partners organize the transcriptional network that defines neural stem cells
oleh: Marti Quevedo, Lize Meert, Mike R. Dekker, Dick H. W. Dekkers, Johannes H. Brandsma, Debbie L. C. van den Berg, Zeliha Ozgür, Wilfred F. J. van IJcken, Jeroen Demmers, Maarten Fornerod, Raymond A. Poot
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-06-01 |
Deskripsi
The Mediator complex regulates transcription by connecting enhancers to promoters. Here, the authors purify Mediator from neural stem cells (NSCs), identify 75 novel protein-protein interaction partners and characterize the Mediator-interacting network that regulates transcription and establishes NSC identity.