Primer synthesis by a eukaryotic-like archaeal primase is independent of its Fe-S cluster
oleh: Sandro Holzer, Jiangyu Yan, Mairi L. Kilkenny, Stephen D. Bell, Luca Pellegrini
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-11-01 |
Deskripsi
Primase is the specialised DNA-dependent RNA polymerase responsible for the initiation of DNA synthesis during DNA replication. Here the authors use a structural biology approach to identify the initiation site in the S. solfataricus PriSLX primase and to demonstrate that its Fe-S cluster is dispensable for primer synthesis.