Activity Dependence of a Novel Lectin Family on Structure and Carbohydrate-Binding Properties
oleh: Irina Chikalovets, Alina Filshtein, Valentina Molchanova, Tatyana Mizgina, Pavel Lukyanov, Olga Nedashkovskaya, Kuo-Feng Hua, Oleg Chernikov
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2019-12-01 |
Deskripsi
A GalNAc/Gal-specific lectins named CGL and MTL were isolated and characterized from the edible mussels <i>Crenomytilus grayanus</i> and <i>Mytilus trossulus</i>. Amino acid sequence analysis of these lectins showed that they, together with another lectin MytiLec-1, formed a novel lectin family, adopting β-trefoil fold. In this mini review we discuss the structure, oligomerization, and carbohydrate-binding properties of a novel lectin family. We describe also the antibacterial, antifungal, and antiproliferative activities of these lectins and report about dependence of activities on molecular properties. Summarizing, CGL, MTL, and MytiLec-1 could be involved in the immunity in mollusks and may become a basis for the elaboration of new diagnostic tools or treatments for a variety of cancers.