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Abstract In this article, we debate the existence of solutions for a nonlinear Hilfer fractional differential inclusion with nonlocal Erdélyi–Kober fractional integral boundary conditions (FIBC). Both cases of convex- and nonconvex-valued right-hand side are considered. Our obtained results are new in the framework of Hilfer fractional derivative and Erdélyi–Kober fractional integral with FIBC via the fixed point theorems (FPTs) for a set-valued analysis. Some pertinent examples demonstrating the effectiveness of the theoretical results are presented.