Find in Library

Hyperoside is an active ingredient in plants, such as <i>Hypericum monogynum</i> in Hypericaceae, <i>Crataegus pinnatifida</i> in Rosaceae and <i>Polygonum aviculare</i> in Polygonaceae. Its pharmacologic effects include preventing cancer and protecting the brain, neurons, heart, kidneys, lung, blood vessels, bones, joints and liver, among others. Pharmacokinetic analysis of hyperoside has revealed that it mainly accumulates in the kidney. However, long-term application of high-dose hyperoside should be avoided in clinical practice because of its renal toxicity. This review summarises the structure, synthesis, pharmacology, pharmacokinetics and toxicity of hyperoside.