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Verruca vulgaris (Vv) as named common wart is an epidermal proliferation caused by the Human Papilloma Virus. Due to specialists and equipment requirements as well as high cost, the most effective treatment for wart such as cryosurgery and electrocautery are not most popular, availability and minimally invasiveness of topical agents turned them into the most appropriate and preferred method especially in children and citizens with low incomes. The purpose of this study was evaluating the efficacy of Alum in the treatment of Vv in two cases. Warts have been disappeared and recurrences were not seen for more than one-year follow-up. For years, Alum used as a powerful adjuvant in many types of vaccines based on its role in immune system activation as adjuvant to activation of cytotoxic T-cells.