Linked-read sequencing of gametes allows efficient genome-wide analysis of meiotic recombination
oleh: Hequan Sun, Beth A. Rowan, Pádraic J. Flood, Ronny Brandt, Janina Fuss, Angela M. Hancock, Richard W. Michelmore, Bruno Huettel, Korbinian Schneeberger
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-09-01 |
Deskripsi
Meiotic crossovers (COs) generate genetic variation and ensure proper chromosome segregation. Here, the authors develop a method for identifying COs at kilobase resolution in pooled recombinants using linked-read sequencing data, and apply it to investigate genome-wide CO landscapes of Arabidopsis thaliana.