frailtypack : An R Package for the Analysis of Correlated Survival Data with Frailty Models Using Penalized Likelihood Estimation or Parametrical Estimation

oleh: Virginie Rondeau, Yassin Mazroui, Juan R. Gonzalez

Format: Article
Diterbitkan: Foundation for Open Access Statistics 2012-04-01

Deskripsi

Frailty models are very useful for analysing correlated survival data, when observations are clustered into groups or for recurrent events. The aim of this article is to present the new version of anR package called frailtypack. This package allows to t Cox models andfour types of frailty models (shared, nested, joint, additive) that could be useful for several issues within biomedical research. It is well adapted to the analysis of recurrent events such as cancer relapses and/or terminal events (death or lost to follow-up). The approach uses maximum penalized likelihood estimation. Right-censored or left-truncated data are considered. It also allows stratication and time-dependent covariates during analysis.