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<i>MOV10</i> and <i>MOV10L1</i> both encode ATP-dependent RNA helicases. In mammals, MOV10 and MOV10L1 participate in various kinds of biological contexts, such as defense of RNA virus invasion, neuron system, germ cell and early development. However, <i>mov10</i> and <i>mov10l1</i> in zebrafish are obscure and the evolutionary relationships of <i>mov10</i> among different species remain unclear. In this study, we found MOV10 and MOV10L1 had some variations despite they possessed the conserved feature of RNA helicase, however, they may originate from a single ancestor although they shared limited homology. A single <i>MOV10L1</i> gene existed among all species, while <i>MOV10</i> gene experienced lineage-specific intra-chromosomal gene duplication in several species. Interestingly, the <i>mov10</i> gene expanded to three in zebrafish, which originating from a duplication by whole genome specific duplication of teleost lineage followed by a specific intra-chromosome tandem duplication. The <i>mov10</i> and <i>mov10l1</i> showed distinct expression profiles in early stages, however, in adult zebrafish, three <i>mov10</i> genes exhibited similar diverse expression patterns in almost all tissues. We also demonstrated <i>mov10</i> genes were upregulated upon virus challenge, highlighting they had redundant conserved roles in virus infection. These results provide valuable data for the evolution of <i>MOV10</i> and <i>MOV10L1</i> and they are important to the further functional exploration.