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Wound healing is the regenerative process of original skin structure after destructing by different damage sources. Due to their transdermal delivery capability and high specific surface area, microneedles arrays (MAs) have been recognized as encouraging biomaterials for wound healing. In this review, we have outlined the engineered MAs used for tissue regeneration and wound healing. Engineered MAs were first classified by design methodologies such as bionic design, intelligent-responsive design, actively-triggered design, matrix materials innovation, and composite smart design. Then, the MAs were divided into two categories based on the different loading substances: drug-loaded MAs and living component-loaded MAs. Finally, we have summed up the important elements of the preceding discussions and forecasted their future evolution.