Kinase-dead ATR differs from ATR loss by limiting the dynamic exchange of ATR and RPA
oleh: Demis Menolfi, Wenxia Jiang, Brian J. Lee, Tatiana Moiseeva, Zhengping Shao, Verna Estes, Mark G. Frattini, Christopher J. Bakkenist, Shan Zha
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-12-01 |
Deskripsi
ATR kinase is a key regulator of chromosome integrity. Here the authors by analysing the phenotype of a mouse model expressing a kinase-dead ATR, reveal the effect of ATR inhibition compared to ATR loss and its consequences for meiosis, DNA replication, checkpoint activation and genome instability .