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The role of dietary profiles in promoting or reducing the risk of multiple types of cancer is increasingly clear, driving the search for balanced foods and nutraceuticals. The red seaweed <i>Grateloupia turuturu</i> has been used as human food showing a balanced nutritional profile. This study aims to test in vivo chemopreventive effects of <i>G. turuturu</i> against cutaneous pre-malignant lesions in transgenic mice for the human papillomavirus type 16 (HPV16). Forty-four female HPV^+/− or HPV^−/− mice received a standard diet or were supplemented with 10% <i>G. turuturu</i> for 22 consecutive days. Cutaneous lesions (ear and chest skin) were identified histologically. Complementarily, the weights and histology of internal organs as well as blood biochemical and DNA integrity parameters were also assessed. <i>G. turuturu</i> consistently reduced the incidence of epidermal dysplasia induced by HPV16 on both cutaneous sites. Moreover, biochemical, DNA integrity and histological analyses confirmed <i>G. turuturu</i> edibility as no signs of toxicity were found. Dietary supplementation with <i>G. turuturu</i> is an effective and safe chemopreventive strategy in this model.