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Endometriosis and gynaecological cancers: molecular insights behind a complex machinery
oleh: Vaclav Vetvicka, Ludek Fiala, Simone Garzon, Giovanni Buzzaccarini, Milan Terzic, Antonio Simone Laganà
| Format: | Article |
|---|---|
| Diterbitkan: | Termedia Publishing House 2021-12-01 |
Deskripsi
Endometriosis is described as the presence of both endometrial glandular and stromal cells outside the uterine cavity. A major characterization of this disease is ectopic implantation of endometrial cells with increased migration. It is one of the leading causes of morbidity among premenopausal women, with a prevalence of 10–16% of women of reproductive age. Despite over century of intensive research, none of the current treatment options represents a real cure. Based on the current knowledge, endometriosis, particularly its atypical version, is considered to be a transitional form from benign disease to tumour. However, the exact mechanisms of this conversion are still not fully established.