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This paper presents a metamaterial-based flexible wearable ultra-wideband (UWB) antenna for breast imaging and wireless body area network (WBAN) applications. The wearable antenna is required to be a planar and low-profile structure using flexible materials. The proposed antenna comprises two layers of denim (10 × 10 mm2) and felt (10 × 15 mm2). The antenna was integrated with six metamaterial unit cells using a modified grain rice shape within a split ring resonator to enhance the bandwidth, gain, and directivity and reduce the specific absorption rate value to less than 2 W/kg. The proposed antenna operates within a broad bandwidth range (6.5 GHz–35 GHz) with the maximum gain and directivity of 8.85 dBi and 10 dBi, respectively, and a radiation efficiency of more than 70% over its operating frequency band. The results verified good agreement between the simulation and measurement of the proposed technique in detecting an existing tumor with a diameter of 4 mm from any location inside the breast. The results convincingly proved the capability of the proposed wearable UWB antenna system for both WBAN and breast imaging applications.